Impaired Memory Following Repeated Pentylenetetrazol Treatments in Kindled Mice
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چکیده
منابع مشابه
Ivabradine Reduces Seizures in Pentylenetetrazol- Kindled Mice
Methods: Forty Mice were randomly allocated into 4 equal groups; control, PTZ, diazepam (4mg/kg) and ivabradine (10 mg/kg) groups. Kindling model was produced by repeated i.p. administration of PTZ (40mg/kg), every other day for 9 days. Repeated PTZ treatment progressively increased the seizure score with the maximum score reached on day 9. Diazepam and ivabradine were administered intraperiton...
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Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phen...
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Pentylenetetrazol purportedly improves memory in mice. Irwin and Benuazizi (1) suggested that pretrial doses of pentylenetetrazol improve short-term retention, that posttrial doses improve longer-term retention, and that the doses that facilitate retention are much less than those that produce convulsions. We tried to confirm the salient parts of their findings. Our method was similar to theirs...
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Introduction: Epilepsy is a group of chronic neurological disorders characterized by seizures. The aim of the present study was to investigate the effects of pretreatment with Satureja bachtiarica essential oil in preventing epilepsy. Methods: In this experimental study, 50 mice were randomly assigned to five groups of 10 each. The control group received normal saline plus tween80 and, 30 min ...
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Sildenafil is the first marketed phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction and recently, for pulmonary hypertension. While the treatment was found to be highly effective, several adverse effects are associated with this compound. Among numerous central nervous system-related untoward effects, proconvulsant activity was reported. The purpose of this study was to ass...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2012
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.132.179